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Sua estreia no plantel principal da empresa ocorreu em 18 de novembro de 2012 no evento Survivor Series, juntamente com Seth Rollins e Roman Reigns, que formaram o grupo The Shield.
Durante esse período, Ambrose conquistou o Campeonato dos Estados Unidos, que ele manteve por 351 dias, obtendo assim o recorde de maior reinado do título enquanto na posse da WWE.
TACT provides the neuromuscular community (clinicians, researchers, patient advocacy groups and industry) with independent and objective guidance on advancing new therapies (whether novel or repurposed) for neuromuscular diseases.
The goal of each review is to position the potential therapy along a realistic and well informed pathway to clinical trials, and eventual registration, by evaluating the supporting preclinical data and all other critical drug development considerations that are necessary for objective decision-making and for the design and conduct of studies that generate meaningful data and have the potential to be funded longer term.
Over the intensive 7-day course, participants examine case studies, attend highly focused seminars presented by members of the scientific, medical and biomedical regulatory communities and develop creative and novel problem-solving strategies to build uniquely effective teams.
Each morning, attendees will receive lectures on neuromuscular disease genetics and pathophysiology.
Progress Report 7/30/2013: The GIFTED grant of 0,000 enabled Summit to start the manufacture of clinical grade SMT C1100 prior to the completion of a larger funding round, which may enable the start of Phase I clinical trials sooner than anticipated.